All this is in the tradition of Judd Apatow, whose films like "Knocked Up" and "The 40-Year-Old Virgin" melded gross-out humor with emotional and moral themes.
The film was always going to be predictable (that is part of its appeal), yet it feels too panicky to be stylish, and surprisingly tasteless: who could have foreseen that its humor would rely on a gastric gross-out?