Conclusion High concentration of glucose can reduce thickness of Glycocalyx on the surface of human glomerular endothelial cell. At the same time,high glucose can decrease the expression of core protein Sydecan-1 and Glypican-1 of HRGECs.
结论高糖可导致HRGECs表面多糖-蛋白复合物的缺失(厚度减少)和HRGECs膜表面核心蛋白Sydecan-1和Glypican-1的表达减弱。
参考来源 - 高糖对人肾小球内皮细胞膜表面多糖·2,447,543篇论文数据，部分数据来源于NoteExpress
AIM: To determine whether high concentration of glucose inhibits endothelium-dependent vasorelaxation of rabbit aortic artery and possible mechanisms.
目的：研究高浓度葡萄糖是否能抑制兔胸主动脉内皮依赖的血管舒张以及可能的机制。
Exposure of islet cells to high concentration of glucose, dexamethosone and palmitate can reduce the expression of PDX-1, therefore affects the insulin synthesis of islet cells.
高浓度的葡萄糖、糖皮质激素、脂肪酸可抑制PDX-1蛋白的表达，从而抑制胰岛细胞的胰岛素分泌功能。
CONCLUSION: High concentration of glucose inhibited endothelium-dependent vasorelaxation and this effect was unlikely mediated through activating oxygen-derived free radical production.
结论：高浓度葡萄糖抑制内皮依赖的血管舒张，这种作用不是通过增加氧自由基的产生介导的。
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