This is your sign for BIG CHANGE…use it to make big changes in your life.

这是一个可以会带来巨变的星座，利用这一次机会，让自己的生活改头换面吧。

youdao

Instead of trying to make gradual changes in small increments, make big changes.

不要试图进行渐进式的小变革，而要进行大变革。

youdao

In normal times, this makes sense: you shouldn't make big changes in policy until it's clear they're needed.

在平常时期，这也是对的：你不应该对政策进行大的变动，除非你很清楚这是必需的。

youdao

You make not small changes in their chemistry but big changes in their chemistry.

它们的化学性质,就会发生巨大的改变

耶鲁公开课 - 生物医学工程探索课程节选

And when you try to do big things and make big changes, it stirs passions and controversy.

WHITEHOUSE: The 2010 State of the Union Address

Ministers decided not to make big changes to the budget after a committee of AMs expressed reservations about whether their plans were affordable.

BBC: Welsh budget passed after Labour deal with Plaid Cymru

If Republicans are going to ask for big changes to the entitlement programs, they should also be willing to make big changes to their own favorite defense-contractor-entitlement program.

FORBES: Thoughts On The Recently Completed Debt-Ceiling Agreement