Inventions usually make a big difference to people's lives.

发明通常对人们的生活有很大的影响。

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For small mammals, microclimates can make a big difference.

对于小型哺乳动物来说，微气候可以产生很大的影响。

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Your choice of words can make a big difference, too.

你的用词也会产生很大的影响。

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But this year, young voters made up their minds early on, and the astronomical levels of support for Obama made a big difference in the primaries and make a big difference in the general election.

NPR: As Election Day Nears, Poll Data Questioned

Big ratings can make a big difference.

CNN: Gay characters don't always cost TV ad dollars

He says he learned those skills with the management consultancy McKinsey, and says he tries to spend most of his time on the five to 10 really big things that will make a big difference to his companies.

BBC: Working Lives Kenya: CEO