In 2000, a large full-scale trial showed that the only other microbicide candidate, nonoxynol-9, was unsafe when it had been expected to be effective.

在2000年，一个大规模的全面试验显示，只有另外一种抗生素nonoxynol - 9与预期效果不同，其存在安全问题。

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Objective: To study the effect of tea saponin in ameliorating nonoxynol (N-9) spermicidal action in vitro.

目的：观察茶皂素对壬苯醇醚(N 9)的杀精增效作用。

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Wolf also notes another issue of concern: contraceptive lubricants that contain the spermicide, nonoxynol-9.

FORBES: Sex Safety and Personal Lubricants

Nonoxynol-9 is also still used in some brands of condoms, also as a spermatocide.

FORBES: Sex Safety and Personal Lubricants

Nonoxynol-9 was also originally thought to disrupt that capsid, or covering, of the HIV viral particle.

FORBES: Sex Safety and Personal Lubricants