Objective:To explore the application of the generalized estimating equation (GEE)in the repeated measures data.

目的：探讨广义估计方程在临床试验重复测量资料分析中的应用。

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Objective: To explore the application of the mixed linear model in the repeated measures data of clinical trials.

前言：目的：探讨混合线性模型在临床试验重复测量资料分析中的应用。

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Method: the repeated measures data were analyzed with category variance outcome by GEE and conclusions were drawn according to the estimating of parameter and standard error.

方法：利用广义估计方程分析结果指标为分类变量的重复测量资料，通过参数和标准误的估计得出统计学结论。

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