Heart failure causes breathlessness and fatigue that severely limits normal daily activities such as walking.

心脏衰竭引起呼吸困难和疲劳，严重影响行走等正常的日常活动。

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When supine, he had severely reduced blood flow through his brain returning to his heart.

在仰卧的时候，由大脑流向心脏的血流会出现神经性减少。

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All had at least one risk factor for heart disease. These include high blood pressure, high cholesterol, diabetes or being severely overweight.

所有受试者至少有一个患心脏病的风险因素，比如高血压，高胆固醇，糖尿病或严重超重。

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The conventional approach is to keep even a severely diseased heart functioning, if possible, with assist devices.

FORBES: Lonely Heart

But that was before Vioxx (withdrawn because of heart attacks) and Ketek (severely restricted because of liver side effects) and a series of other controversies that resulted in FDA brass being called in front of Congress.

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In July Glaxo pled guilty to U.S. misdemeanor charges that it had marketed the anti-depressants Paxil and Wellbutrin for unapproved uses and had not disclosed clinical data related to the diabetes medicine Avandia, which eventually had its use severely restricted because it may increase the risk of heart attacks.

FORBES: With Transparency Pledge, Glaxo Makes Promises No Other Drug Company Has