tumor suppressor gene p mutation 肿瘤抑制基因p53突变
Pathology: p53 tumor suppressor gene mutation, loss of heterozygosity (LOH) at 11p15 locus. PAX-FKHR gene fusion.
病理学：p53肿瘤抑制基因突变，第11p15基因座杂和性丢失。
The different mechanisms, such as the activation of oncogenes, the inactivation and mutation of tumor suppressor gene, antiapoptosis and so on are involved in .
原癌基因的激活，抑癌基因的失活、突变，抗细胞凋亡等不同的机制都可能参与其中。
Objective: To investigate the mutation of RB tumor suppressor gene in Wilms tumor and to explore the relationship between RB mutation and the pathogenesis of Wilms tumor.
目的：调查肾母细胞瘤中RB基因突变，探讨RB基因突变与肾母细胞瘤发生的关系。
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