The process is generally initiated by the application of carefully controlled conditions such as temperature and pH, so as to achieve cell death with out inactivating the natural hydrolytic enzyme.

这个过程一般通过控制温度、pH值而开始启动，就是让细胞失活但天然水解酶并不失活。

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Peroxynitrites contribute to the hyperphosphorylation of tau proteins by oxidating g-protein coupled receptors and trysoine kinase receptors preventing protein kinase C and AKT from inactivating the enzyme GSK3 which is necessary to prevent the hyperphosphorylation of tau proteins.

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