Inventions usually make a big difference to people's lives.

发明通常对人们的生活有很大的影响。

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For small mammals, microclimates can make a big difference.

对于小型哺乳动物来说，微气候可以产生很大的影响。

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Your choice of words can make a big difference, too.

你的用词也会产生很大的影响。

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A few degrees can make a big difference when it comes to food storage.

VOA: special.2009.02.09

But whether or not you do so doesn't seem to make a big difference.

但不论你是否选择这样做,都不会有什么太大的影响

耶鲁公开课 - 心理学导论课程节选

Primarily the people who started are Emerson and Moscovici and many others who have done research showing how minority-- very often one person can make a big difference, can make a significant difference.

爱默生和莫斯科维奇是先驱,他们和其他学者都证明少数人-,经常是一个人，如何实现重大改变，能实现显著的改变。

哈佛公开课 - 幸福课课程节选

But this year, young voters made up their minds early on, and the astronomical levels of support for Obama made a big difference in the primaries and make a big difference in the general election.

NPR: As Election Day Nears, Poll Data Questioned

Big ratings can make a big difference.

CNN: Gay characters don't always cost TV ad dollars

He says he learned those skills with the management consultancy McKinsey, and says he tries to spend most of his time on the five to 10 really big things that will make a big difference to his companies.

BBC: Working Lives Kenya: CEO