In 1994, Zhang et al. cloned the structure of the mouse obese(ob) gene and its human homologue by positional cloning. The protein named leptin is the product of the ob gene.
1994 年,Zhang 等学者利用定位克隆技术成功克隆了小鼠的肥胖基因(obese gene, ob )及人类的同源序列,ob 基因编码的蛋白质产物被称为leptin,译为瘦素。
参考来源 - leptin调节下丘脑神经肽Y分泌的研究Using positional cloning approach, our laboratory had characterized the candidate gene of POS as a transcription factor encoding a C2H2 zinc-finger protein, closely homologous to Arabidopsis JAGGED (JAG).
利用图位克隆方法,本实验室已确定POS的侯选基因是一个编码C2H2 zinc-finger蛋白的转录因子,与拟南芥的JAG基因同源。
参考来源 - 水稻花器官发育控制基因POS的功能和表达分析·2,447,543篇论文数据，部分数据来源于NoteExpress
To identify the gene mutation for congenital alopecia by positional cloning or positional candidate cloning technique.
通过定位克隆或定位后选克隆技术识别先天性秃发的致病基因。
All in all, it is responsible to apply this kind of positional cloning strategy for finding the disease gene in this big family.
总之，本研究所采用的定位方法对于这个家系的致病基因的准确定位是合理的。
These results provide essential information for further utilization of the blast resistance gene in Ziyu 44 in rice disease resistance breeding and positional cloning of the gene.
这些结果为进一步将子预44中的抗性基因用于水稻抗病育种及该抗稻瘟病基因的克隆奠定了重要基础。
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