Of course, this is a big problem.

那是当然。这可是个大问题。

youdao

I think this is a big problem - much bigger than we think.

我认为这是一个大问题，比我们想得还要大。

youdao

This is a big problem.

这是个大问题。

youdao

This is a big problem in poor countries.

VOA: special.2010.02.24

This is a big problem. -Interesting.

这可是个大问题，-挺有趣。

普林斯顿公开课 - 人性课程节选

A big problem with this is a lot of Freudian theory is claimed to be validated in the course of psychoanalysis.

这里存在的一个大问题便是,精神分析理论中的很多内容,被认为是能够在精神分析的过程中,得到证实的。

耶鲁公开课 - 心理学导论课程节选

This is a big problem, and all of us are called on to solve it.

WHITEHOUSE: President Obama Takes Questions at GOP House Issues Conference | The White House

Let me say, this is a big problem everywhere in the world.

BBC: News | Monitoring | President Clinton on Shanghai radio phone-in

Hard to imagine that this is a big problem?

FORBES: Cooking with Julia Roberts