"What is it?" his wife asked again, gently but insistently.

“这是什么？”他妻子再次问道，语气温和但很坚决。

《柯林斯英汉双解大词典》

What is it that's troubling you?

是什么事使得你愁眉苦脸？

《牛津词典》

What is it you want to see me about?

你找我有什么事？

《牛津词典》

ALLEN: "What is it,Mister Benny?" BENNY: "Oh,Mister Allen,have you heard that they're making women's bathing suits out of spun glass?"

VOA: special.2009.03.09

Specifically, what is it that American companies that, both then and now, still don't understand about China that you think you do and they don't?

美国公司对于中国的互联网行业，始终不甚了解,能否谈谈一些你知道而别人不知道的原因？

斯坦福公开课 - 百度CEO李彦宏演讲：全球最大搜索引擎的发展课程节选

What is it the Israelites were saying in their day and in their time and against whom and for what?"

当时的犹太人在生活中都说些什么？”,“反驳谁？为什么？”

耶鲁公开课 - 旧约导论课程节选

So what is it that drives people to want to leave this planet and risk everything on another?

BBC: Prospect of one-way Mars trip captures the imagination

But we have seen is, what is it, 2.4 million private sector jobs created.

WHITEHOUSE: Press Briefing

What does the biotech rider actually state and what is it designed to address?

FORBES: Exposing the Anti-GMO Legal Machine: The Real Story Behind the So-Called Monsanto Protection Act