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If you say that someone is a wise guy, you dislike the fact that they think they are very clever and always have an answer for everything. 自作聪明的人; 自以为无所不知的人
[非正式]
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A wise guy is a member of the Mafia. 黑手党成员
[美国英语][非正式]
He's an original, this date doctor trying to heal himself, and it's exciting to see Mr. Smith plays it all -- a wise man, a wiseguy, a straight man or an antic fool, yet always a good guy, and a passionate one.
Duke Nukem burst onto the scene in 1991 as the wise-cracking, cigar-chomping, woman-loving tough guy who must save the Earth from invading aliens, and does so with all the irreverence and hyper-masculinity of a Hollywood action hero.