Feelings of guilt, worthlessness, or helplessness.

负罪感，价值感缺失或无助感。

youdao

Do you feel worthlessness or excessive guilt nearly every day?

你是否整天觉得没有价值或者很有负罪感？

youdao

People can't afford repairs or gasoline, so many of the Jaguars rust away to worthlessness.

人们没钱修理或汽油，许许多多的捷豹汽车锈得毫无价值。

youdao

The two subjects of conversation were the superiority of entrepreneurship and the worthlessness of higher education.

NEWYORKER: No Death, No Taxes

For instance, there may be feelings of worthlessness, loneliness, panic, anger, guilt, rejection, self-hatred or confused sexuality.

CNN: Self-injury/cutting

When they are depressed however they feel low, are often tired and might have sleep problems, feelings of worthlessness and guilt.

BBC: NEWS | Health | Call for mental disorder checks