In the super early phase of acute cerebral ischemia, many therapeutic drugs cannot penetrate into the complete blood-brain barrier (BBB) and enter brain tissues within the effective time window.
在急性脑缺血的超早期，完整的血脑屏障(BBB)使许多治疗药物无法在有效治疗时间窗内进入脑组织发挥作用。
Objective To explore the effect of thrombin (TB) on the blood brain barrier(BBB) permeability and its possible mechanism.
目的探讨凝血酶（TB）对血脑屏障通透性的影响及其可能机制。
Aim to synthesize acylated prodrug of tacrine hydrochloride (THA) to improve the infiltration ability across the blood brain barrier (BBB).
目的制备盐酸他克林(THA)的酰化前体药物以提高其透过血脑屏障(BBB)的能力。
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