Aim to synthesize acylated prodrug of tacrine hydrochloride (THA) to improve the infiltration ability across the blood brain barrier (BBB).

目的制备盐酸他克林(THA)的酰化前体药物以提高其透过血脑屏障(BBB)的能力。

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Objective To explore the effect of thrombin (TB) on the blood brain barrier(BBB) permeability and its possible mechanism.

目的探讨凝血酶（TB）对血脑屏障通透性的影响及其可能机制。

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NP-SLE patients with local CNS involvements showed mainly the damage of blood brain barrier(BBB) .

相反，局限性CNS受损患者主要表现为血脑屏障（BBB）破坏。

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