In the super early phase of acute cerebral ischemia, many therapeutic drugs cannot penetrate into the complete blood-brain barrier (BBB) and enter brain tissues within the effective time window.
在急性脑缺血的超早期，完整的血脑屏障(BBB)使许多治疗药物无法在有效治疗时间窗内进入脑组织发挥作用。
Reactive oxygen species (ROS) are mediators of demyelination and disruption of the blood-brain barrier (BBB).
活性氧簇(ROS)是神经系统脱髓鞘及血脑屏障破坏的媒介。
Aim to synthesize acylated prodrug of tacrine hydrochloride (THA) to improve the infiltration ability across the blood brain barrier (BBB).
目的制备盐酸他克林(THA)的酰化前体药物以提高其透过血脑屏障(BBB)的能力。
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