The world rarely sees someone who has had such a profound impact on so many.
Retrofit program, and it can have a profound impact on reducing healthcare costs for corporate America.
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But her involvement in the campaign has a profound impact on her family, friends and community.
The actions of the federal government can have a profound impact on financial markets.
This demographic trend will have a profound impact on medical costs, businesses, worker efficiency and productivity.
The greed and hubris displayed on these pages had a profound impact on our economic history.
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None of this is to deny that the unions could again have a profound impact on politics.
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Bringing robotics technology to students in disadvantaged communities can have a profound impact at every grade level.
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Research suggests that the way we wish to perceive ourselves has a profound impact on how we behave.
This is having a profound impact on the market for developing new tests.
And finally, our newest program which is having a profound impact on education in Chicago is the Saturday University.
These new technologies, combined with demographic shifts and globalisation, will have a profound impact on the future of SMEs.
But one way or another, the case of one errant congressman may have a profound impact on the voting pattern.
The study found that the food in the far corner of the room had a profound impact on these predictions.
Some noted French trends of the past such as Japonisme and Chinoiserie have made a profound impact on French culture.
When integrated into games, virtual worlds and other simulated environments, this technology will have a profound impact on the user's experience.
It's these kind of skills - and others - that would have such a profound impact on teenagers' outlook on life.
Mark Zuckerberg is the youngest billionaire on the planet and created something that has already had a profound impact on the world.
And all of us have to be concerned about a changing climate that could have a profound impact on every single country here.
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It was the first time a President had addressed the nation in such an intimate and informal way, and it had a profound impact.
All this could have a profound impact on the United States, which in recent years has absorbed about half of each new Mexican generation.
The Lao government has plans to build a series of dams along the Nam Ou River, which would have a profound impact on the area.
The world rarely sees someone who made such a profound impact.
Whatever controversy dogged the company with Mass Effect 3 and Dragon Age 2, Bioware has had a profound impact on the ascendance of Western RPGs.
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"If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality, " Westin said.
And so the chances are that if this continues, and there's no reason why it shouldn't continue, it will have a profound impact on the November election.
In Central California, the nation's agricultural powerhouse and a region with one of the highest poverty levels, the 1986 law had a profound impact on people like Mejia.
But to have the vast majority of a commission that had a profound impact upon White House-level policy so unbalanced towards industry executives and consultants is also irresponsible.
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Revenue sharing also had a profound impact on operating income.
But I think the elephant in the room for the Republican Party is the war, and I think for Senator Domenici coming out yesterday, that's going to have a profound impact.
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