American officials say the agreement benefits both sides, and any significant change could unravel the whole deal.

VOA: standard.2009.10.20

Singapore's Finance Minister Tharman Shanmugaratnam said none of the ministers called for any sudden or significant change in exchange rates, but said they should remain flexible.

VOA: standard.2009.11.12

American Heart Association spokesman Dr.Donald LaVan explains why that change in the arteries is significant.

VOA: standard.2010.03.04

"Whether or not they blame Karzai for that personally, I think that there is a general sense among significant parts of the population that it may be time for a change.

VOA: standard.2009.08.03

"I think that you're going to see some significant additional sanctions imposed by the international community, assuming that the Iranians don't change course and agree to do the things they signed up to do at the beginning of October,".

VOA: standard.2009.12.12