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He spoke slowly and with great difficulty.

他话说得很慢，而且很吃力。

《牛津词典》

I had great difficulty getting off to sleep.

我很难入睡。

《牛津词典》

As a young child, Clara had great difficulty studying and making friends at school.

VOA: special.2009.07.26

The difficulty of the poem lies to a great degree, I think, in something that Dr. Johnson had noted in his attack or in his criticism on Lycidas that I mentioned on Monday.

诗歌本身的难点很大程度上，在于约翰逊博士在他对利西达斯的,抨击中提到的一些点。

耶鲁公开课 - 弥尔顿课程节选

I had to try something. I could still move with great difficulty.

VOA: special.2010.07.31

You know, people ask me how why did this, and with great difficulty, in many ways.

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We would have had very great difficulty trying to respond to a crisis of equal proportion.

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And a big part of the problem is that they have great difficulty finding work.

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